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Literature summary extracted from

  • Lin, Y.; Gao, Y.; Ma, Z.; Li, Z.; Tang, C.; Qin, X.; Zhang, Z.; Wang, G.; Du, L.; Li, M.
    Bioluminescent probe for detection of starvation-induced pantetheinase upregulation (2018), Anal. Chem., 90, 9545-9550 .
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.5.1.92 additional information
-
 additional information Michaelis-Menten kinetics and Lineweaver-Burk plots Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
3.5.1.92 Mus musculus Q9Z0K8
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.5.1.92 intestine
-
 Mus musculus
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3.5.1.92 kidney
-
 Mus musculus
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3.5.1.92 liver
-
 Mus musculus
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3.5.1.92 additional information pantetheinase is a glycosylphosphatidylinositol (GPI) anchored enzyme, overexpressed in intestine, liver, and kidney Mus musculus
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.1.92 2-(6-[[N-(2,4-dihydroxy-3,3-dimethylbutanoyl)-beta-alanyl]amino]-1,3-benzothiazol-2-yl)-4,5-dihydro-1,3-thiazole-5-carboxylic acid + H2O design, synthesis, and biological examination of a highly sensitive bioluminogenic probe for pantetheinase with a limit of detection of 1.14 ng/ml. Validation of the probe for application to detect the endogenous pantetheinase activity, overview Mus musculus 2-(6-amino-1,3-benzothiazol-2-yl)-4,5-dihydro-1,3-thiazole-5-carboxylic acid + N-(2,4-dihydroxy-3,3-dimethylbutanoyl)-beta-alanine
-
 ir

Synonyms

EC Number Synonyms Comment Organism
3.5.1.92 pantetheinase
-
 Mus musculus

Expression

EC Number Organism Comment Expression
3.5.1.92 Mus musculus starvation-induced pantetheinase upregulation up

General Information

EC Number General Information Comment Organism
3.5.1.92 physiological function pantetheinase is a glycosylphosphatidylinositol (GPI) anchored enzyme, overexpressed in intestine, liver, and kidney with various biological functions such as its linkage to the inflammation and some metabolic diseases. It can hydrolyze pantetheine to cysteamine, an antioxidant, and pantothenic acid (vitamin B5) that is an essential component of coenzyme A (CoA). Starvation induces pantetheinase upregulation Mus musculus